Posted by: adamhuber888 | January 3, 2012

Aging slowed in mice with supplement mix

This CBC radio article by Kelly Crowe, reads like a primer for metabolic Therapy. Thirty one vitamin/mineral supplements were given to a group of mice and were later compared to the control group, which received a regular diet. The results were dramatic and are similar to what I see in those people who follow the principles of Metabolic Therapy. The article includes the list of vitamins and minerals given in the trial.

(see: http://www.metabolictherapy.org)

Aging slowed in mice with supplement mix

CHASING CURES | CBC News examines how close we are to finding cures for aging, obesity, diabetes, the common cold and cancer in a series of special reports

CBC News

Posted: Jan 2, 2012 4:40 AM ET

Last Updated: Jan 2, 2012 11:16 AM ET

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Earl Fee, 82, credits his intense training regime for his vitality.Earl Fee, 82, credits his intense training regime for his vitality. (Courtesy of Ontario Masters Athletics)

It might be possible to cure aging, say scientists who’ve found that lab mice get smarter and more agile as they age when fed a mix of nutritional supplements.

The diet and supplement plan isn’t a conventional “cure.” But the animal results at McMaster University in Hamilton illustrate how investigators aim to slow down the aging process to avoid the physical and mental declines that often come as more candles are added to the birthday cake.

At Prof. David Rollo’s biology laboratory, mice that ate bagel bits soaked in a cocktail of supplements such as B vitamins, vitamin D, ginseng and garlic lived longer than those not taking the special mice chow.

“If you put them on a supplement, they actually learn better as they age,” Rollo said. “They still don’t live much longer but their brain function is remarkable.”

The mice also acted like restless teenagers showing “spontaneous motor function” that fades in humans in a universal sign of aging, Rollo added.

The supplemented mice maintained their memory function in tests, such as remembering a familiar object. Their learning abilities were like those of very young mice, he said. Mice of the same age that were not supplemented behaved in lab tests like a frail 80-year-old woman.

Investigators turned to the cocktail of ingredients based on their suspected ability to offset five key mechanisms involved in aging.

Available at health food stores

The researchers have also doubled the lifespan of crickets using a combination of dietary restriction and supplements, and other investigators have found similar results in other animal models.

Most of the supplements Rollo and his team use are sold at health food stores. But he cautioned they are not something to be toyed with because the cocktail hasn’t been tested to see if it is safe for people.

The supplements cross the blood-brain barrier to affect the mitochondria “furnaces” in the brain in a fundamental way, he noted.

Scientists still don’t how the supplements actually work and interact in the body.

Live to 1,000?

Like Rollo, British gerontologist Aubrey de Grey of Cambridge is optimistic about the potential to extend human life span, but he takes a different approach. He’s not trying to eliminate aging but to extend how long people can be fit and healthy.

“We know that with simple man-made machines like cars and airplanes, we don’t have a limit,” said de Grey said, who acknowledged that humans are more complicated.These mice are the same age but one received the supplements and one didn’t.These mice are the same age but one received the supplements and one didn’t.(Courtesy of David Rollo)

“We can keep these machines going … just by doing sufficiently comprehensive repair and maintenance reasonably often and that is going to be exactly the same for the human body.”

By bringing the molecular and cellular damage that accumulates throughout life under medical control, de Grey suspects that human life spans could be vastly extended.

“If you reach age 26, what is the chance of not reaching 27? The answer is less than one in a thousand. So if you maintain that risk then clearly you [can] live a four-digit lifespan. You will live 1,000 years or more.”

Earl Fee of Mississauga, Ont., has a more modest goal: to live to 120.

Fee was a runner in his youth and then stopped for years. He resumed running at the age of 57 and now competes.

“I am 82 but I don’t feel much different than when I was 32, so that is a very good feeling,” he said.

Earl credited his intense training regime, healthy diet, enjoying a glass or two of red wine before dinner and the fortune of good genes for his vitality.

“Before I ran, I wasn’t as energetic or as vibrant,” he recalled.

Cocktail ingredients
Ingredient Mouse dose (mg/day/100 mice)
Vitamin B1 30.49
Ginko biloba 18.29
Vitamin B3 (niacin) 30.49
Ginseng 631.1
Vitamin B6 60.98
Green tea extract 487.8
Vitamin B12 0.18
L-Glutathione 30.49
Vitamin C 350.61
Magnesium 45.73
Vitamin D 0.02
Manganese 19.05
Acetyl L-carnitine 146.45
Melatonin 0.73
Alpha-lipoic acid 182.93
N-acetyl cysteine 304.88
Acetylsalicylic acid 132.11
Potassium 18.11
Beta carotene 21.95
Rutin 304.88
Bioflavonoids 792.68
Selenium 0.05
Chromium picolinate 0.30
Vitamin E 326.83
Folic acid 0.61
Cod liver oil (Omega 3) 1,219.51
Garlic 3.81
Coenzyme Q10 60.98
Ginger root extract 600.37
Flax seed oil 1,219.51
Source: Experimental Biology and Medicine

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